Product Overview
ML216 | T5413 | TargetMol Chemicals
CAS: 1430213-30-1
Smiles: Fc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C(F)(F)F
Formula: C15H9F4N5OS
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: DNA/RNA Synthesis
Receptor: N/A
Bioactivity: ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 μM).
Molecular Weight: 383, 32
