Product Overview
ML221 | T4390 | TargetMol Chemicals
CAS: 877636-42-5
Smiles: [O-][N+](=O)c1ccc(cc1)C(=O)Oc1coc(CSc2ncccn2)cc1=O
Formula: C17H11N3O6S
Pathway: GPCR/G Protein
Target: Apelin receptor
Receptor: N/A
Bioactivity: ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
Molecular Weight: 385, 35