Product Overview
MLi-2 | T16115 | TargetMol Chemicals
CAS: 1627091-47-7
Smiles: [H][C@]1(C)CN(C[C@@]([H])(C)O1)c1cc(ncn1)-c1n[nH]c2ccc(OC3(C)CC3)cc12
Formula: C21H25N5O2
Pathway: Autophagy
Target: LRRK2
Receptor: N/A
Bioactivity: MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
Molecular Weight: 379, 464
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