Product Overview
Momelotinib | T1849 | TargetMol Chemicals
CAS: 1056634-68-4
Smiles: O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Formula: C23H22N6O2
Pathway: Angiogenesis|||Apoptosis|||Autophagy|||Chromatin/Epigenetic|||JAK/STAT signaling|||Stem Cells
Target: Apoptosis|||JAK|||Autophagy
Receptor: N/A
Bioactivity: Momelotinib is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.
Molecular Weight: 414, 469
