Product Overview
MPT0B206 | T28092 | TargetMol Chemicals
CAS: T28092
Smiles: O=CNC1=CC=CC2=C1N(S(=O)(C3=CC=C(OC)C=C3)=O)CC2
Formula: C16H16N2O4S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1 and the dephosphorylation of Cdc2. Treatment of K562 and K562R cells with MPT0B206 induced apoptosis and reduced the protein levels of procaspase-9 and procaspase-3 and increased caspase-3 activity and PARP cleavage.
Molecular Weight: 332, 37