Product Overview
MS-073 | T33510 | TargetMol Chemicals
CAS: 129716-45-6
Smiles: OC(COc1cccc2ncccc12)CN1CCN(CC1)C1c2ccccc2CCc2ccccc12
Formula: C31H33N3O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: MS-073 (CP-162398) is a P-glycoprotein inhibitor (P-gp). The in vitro resistance to vincristine (VCR) was almost completely reversed in VCR-resistant P388 cells, and the resistance of VCR, adriamycin (ADM), etoposide, and actinomycin D in ADM-resistant human myeloid leukemia K562 (K562/ADM) cells in vitro was also reversed. MS-073 reverses MDR by competitively inhibiting the binding of drugs to P-glycoprotein.
Molecular Weight: 479, 624
