Product Overview
MS2177 | T28114 | TargetMol Chemicals
CAS: T28114
Smiles: COC1=C(OCCN)C=C(N=C(N2CCCC2)N=C3NCCCCCN4CCCC4)C3=C1
Formula: C24H38N6O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillation proximity assay. Binding of MS2177 to SETD8 was confirmed by isothermal titration calorimetry (ITC), having a KD of 1.3 μM.
Molecular Weight: 442, 61