Product Overview
MSC 2032964A | T33514 | TargetMol Chemicals
CAS: 1124381-43-6
Smiles: FC(F)(F)c1cc(NC2CC2)n2nc(NC(=O)c3cccnc3)nc2c1
Formula: C16H13F3N6O
Pathway: Apoptosis
Target: ASK
Receptor: N/A
Bioactivity: MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
Molecular Weight: 362, 316
