Product Overview
MTI-31 | T35343 | TargetMol Chemicals
CAS: 1567915-38-1
Smiles: C[C@@H](COCC1)N1c1nc(N2C3COCC2CC3)c(ccc(-c2cccc(C(NC)=O)c2)n2)c2n1
Formula: C26H30N6O3
Pathway: PI3K/Akt/mTOR signaling
Target: mTOR
Receptor: N/A
Bioactivity: MTI-31 is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5, 000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 μM ATP[1].
Molecular Weight: 474, 55
