Product Overview
Murrangatin | TN4592 | TargetMol Chemicals
CAS: 37126-91-3
Smiles: COc1ccc2ccc(=O)oc2c1[C@@H](O)[C@@H](O)C(C)=C
Formula: C15H16O5
Pathway: Apoptosis|||GPCR/G Protein|||Immunology/Inflammation|||Neuroscience
Target: IL Receptor|||TNF|||COX|||Prostaglandin Receptor
Receptor: N/A
Bioactivity: Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. Murrangatin exhibits antibacterial activity against P. gingivalis (ATCC 33277). Murrangatin also shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9±6.5uM. Murrangatin and murracarpin may be a new backbone for developing inhibitors of cyclooxygenase 2, they show chondroprotective activity by downregulation of interleukin-1β, tumor necrosis factorα, prostaglandins E2, and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2.
Molecular Weight: 276, 3
