Product Overview
Naftifine hydrochloride | T1543 | TargetMol Chemicals
CAS: 65473-14-5
Smiles: Cl.CN(C\C=C\c1ccccc1)Cc1cccc2ccccc12
Formula: C21H22ClN
Pathway: GPCR/G Protein|||Microbiology/Virology|||Stem Cells
Target: Hedgehog/Smoothened|||Antibiotic|||Antifungal
Receptor: N/A
Bioactivity: Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2, 3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved.
Molecular Weight: 323, 86
