Product Overview
NAMPT inhibitor-linker 2 | T18478 | TargetMol Chemicals
CAS: 2241014-82-2
Smiles: Fc1cc(NC(=O)[C@H]2C[C@@H]2c2cccnc2)ccc1CNC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)CCN1C(=O)C=CC1=O
Formula: C34H33FN6O5
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: NAMPT inhibitor-linker 2 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
Molecular Weight: 624, 673
