Product Overview
β-Naphthoflavone-CH2-OH | T17363 | TargetMol Chemicals
CAS: T17363
Smiles: O=C1C=C(C2=CC=C(CO)C=C2)OC3=C1C4=CC=CC=C4C=C3
Formula: C20H14O3
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for arylhydrocarbon receptor (AhR) E3 ligase. β-Naphthoflavone-CH2-OH can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1) that recruit the AhR E3 ligase complex by incorporating AhR ligands into chimeric molecules. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins [1].
Molecular Weight: 302, 32
