Product Overview
Navtemadlin | TQ0127 | TargetMol Chemicals
CAS: 1352066-68-2
Smiles: CC(C)[C@@H](CS(C(C)C)(=O)=O)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cccc(Cl)c2)c(cc2)ccc2Cl)C1=O
Formula: C28H35Cl2NO5S
Pathway: Apoptosis|||Ubiquitination
Target: Mdm2|||E1/E2/E3 Enzyme
Receptor: N/A
Bioactivity: AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
Molecular Weight: 568, 55