Product Overview
Necrosulfonamide | T6904 | TargetMol Chemicals
CAS: 1360614-48-7
Smiles: COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)\C=C\c2ccc(s2)[N+]([O-])=O)cc1
Formula: C18H15N5O6S2
Pathway: MAPK
Target: MLK
Receptor: N/A
Bioactivity: (E)-Necrosulfonamide is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.
Molecular Weight: 461, 47
