Product Overview
Nedaplatin | T2410 | TargetMol Chemicals
CAS: 95734-82-0
Smiles: N.N.[Pt++].[O-]CC([O-])=O
Formula: C2H8N2O3Pt
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: DNA/RNA Synthesis
Receptor: N/A
Bioactivity: Nedaplatin is a derivative of cisplatin and DNA damage agent for tumor colony forming units (IC50: 94 μM). Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucleophilic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death.
Molecular Weight: 303, 181
