Product Overview
Negletein | T2S0843 | TargetMol Chemicals
CAS: 29550-13-8
Smiles: COc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1
Formula: C16H12O5
Pathway: Apoptosis|||Immunology/Inflammation
Target: IL Receptor|||TNF|||NOS|||Interleukin
Receptor: N/A
Bioactivity: 1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.
Molecular Weight: 284, 267