Product Overview
NF157 | T16291 | TargetMol Chemicals
CAS: 104869-26-3
Smiles: Fc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2F)C(=O)Nc2ccc(c3cc(cc(c23)S(=O)(=O)O[Na])S(=O)(=O)O[Na])S(=O)(=O)O[Na])c1)C(=O)Nc1ccc(c2cc(cc(c12)S(=O)(=O)O[Na])S(=O)(=O)O[Na])S(=O)(=O)O[Na]
Formula: C49H28F2N6Na6O23S6
Pathway: Immunology/Inflammation|||Neuroscience
Target: COX
Receptor: N/A
Bioactivity: NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35). The IC50s are 463 nM, 1811 μM, 170 μM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 μM), P2Y2 (Ki=28.9 μM), respectively.
Molecular Weight: 1437, 08