Product Overview
Nigericin | T16323 | TargetMol Chemicals
CAS: 28380-24-7
Smiles: [H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C(O)=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C
Formula: C40H68O11
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin can be an NLRP3 activator that causes the release of IL-1β as a NALP3-dependent manner. Nigericin induces eryptosis, an effect paralleled by ROS formation, and in part due to the induction of oxidative stress. Nigericin causes apoptosis.
Molecular Weight: 724, 973
