Product Overview
Nimbolide | T16324 | TargetMol Chemicals
CAS: 25990-37-8
Smiles: [H][C@@]12CC(C(C)=C1[C@@]1(C)[C@H](CC(=O)OC)[C@]3(C)C4[C@@]([H])(OC(=O)[C@]4(C)C=CC3=O)[C@@]1([H])O2)c1ccoc1
Formula: C27H30O7
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||NF-Κb
Target: Apoptosis|||NF-κB|||CDK
Receptor: N/A
Bioactivity: Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica L).
Molecular Weight: 466, 53
