Product Overview
NKH477 | T16332 | TargetMol Chemicals
CAS: 138605-00-2
Smiles: Cl.[H][C@@]12[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
Formula: C27H44ClNO8
Pathway: Neuroscience
Target: NMDAR
Receptor: N/A
Bioactivity: NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts. NKH477 directly activates the catalytic unit of adenylate cyclase and enhances intracellular cAMP .
Molecular Weight: 546, 1