Product Overview
NLCQ-1 HCl | T33699 | TargetMol Chemicals
CAS: 221292-08-6
Smiles: Cl.[O-][N+](=O)c1nccn1CCCNc1ccnc2cc(Cl)ccc12
Formula: C15H15Cl2N5O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: NLCQ-1 is a novel weak DNA-intercalative bioreductive compound. NLCQ-1 exhibited a C50 of 44 microM. NLCQ-1 demonstrated significant hypoxic selectivity in several rodent (V79, EMT6, SCCVII) or human (A549, OVCAR-3) tumor cell lines. Its potency as a hypoxic cytotoxin ranged between 10 and 136 microM x h, for the cell lines tested, at 30 microM input concentration. NLCQ-1 was a very potent and efficient radiosensitizer of hypoxic V79 cells, providing SER values of 2.27-2.56 at 20-80 microM concentration (measured at 10% survival level). Preclinical results suggest a possible use of NLCQ-1 as adjuvants to radiotherapy.
Molecular Weight: 368, 22
