Nortopixantrone HCl | T28189

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TMC-T28189
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Product Overview

Nortopixantrone HCl | T28189 | TargetMol Chemicals

CAS: 438244-41-8

Smiles: Cl.Cl.CNCCNc1ccc2n(CCNCCO)nc3-c4cnccc4C(=O)c1c23

Formula: C20H26Cl2N6O2

Pathway: N/A

Target: N/A

Receptor: N/A

Bioactivity: Nortopixantrone is a DNA topoisomerase inhibitor. BR 3438 exhibited a superior efficacy against prostatic carcinoma models compared to reference compounds ( losoxantrone and doxorubicin). The antitumour efficacy of BBR 3438 against prostatic carcinoma could be the result of a combination of favourable events, including enhanced intracellular accumulation and an increased DNA-binding affinity favouring the accumulation of multiple sublethal or lethal damage.

Molecular Weight: 453, 37

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