Product Overview
Nortopixantrone HCl | T28189 | TargetMol Chemicals
CAS: 438244-41-8
Smiles: Cl.Cl.CNCCNc1ccc2n(CCNCCO)nc3-c4cnccc4C(=O)c1c23
Formula: C20H26Cl2N6O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Nortopixantrone is a DNA topoisomerase inhibitor. BR 3438 exhibited a superior efficacy against prostatic carcinoma models compared to reference compounds ( losoxantrone and doxorubicin). The antitumour efficacy of BBR 3438 against prostatic carcinoma could be the result of a combination of favourable events, including enhanced intracellular accumulation and an increased DNA-binding affinity favouring the accumulation of multiple sublethal or lethal damage.
Molecular Weight: 453, 37
