NS13001 | T16345

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€170.00 - €1,637.00
SKU:
TMC-T16345
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Product Overview

NS13001 | T16345 | TargetMol Chemicals

CAS: 1063331-94-1

Smiles: Cc1cc(C)n(n1)-c1nc(Nc2ccc(Cl)cc2)c2ncn(C)c2n1

Formula: C17H16ClN7

Pathway: Membrane transporter/Ion channel

Target: Potassium Channel

Receptor: N/A

Bioactivity: NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias.

Molecular Weight: 353, 81

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