NS309 | T4612

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€167.00 - €395.00
SKU:
TMC-T4612
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Product Overview

NS309 | T4612 | TargetMol Chemicals

CAS: 18711-16-5

Smiles: O\N=C1\C(=O)Nc2c1ccc(Cl)c2Cl

Formula: C8H4Cl2N2O2

Pathway: Angiogenesis|||JAK/STAT signaling|||Membrane transporter/Ion channel|||Tyrosine Kinase/Adaptors

Target: EGFR|||Potassium Channel|||HER

Receptor: N/A

Bioactivity: NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7, 400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.

Molecular Weight: 231, 03

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