Product Overview
NS3861 | T9542 | TargetMol Chemicals
CAS: 216853-59-7
Smiles: CN(C(CC1)C2)C1C=C2c(scc1)c1Br
Formula: C12H14BrNS
Pathway: Neuroscience
Target: AChR
Receptor: N/A
Bioactivity: NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-containing receptors. The maximal efficacy of NS3861 appeared solely dependent on the nature of the ligand-binding domain. Furthermore, a principal subunit serine to threonine substitution may explain the lack of NS3861 activation at α4-containing receptors.
Molecular Weight: 284, 21