Product Overview
NTRC 0066-0 | T28216 | TargetMol Chemicals
CAS: 1817791-73-3
Smiles: CCc1cccc(CC)c1NC(=O)c1ccn-2c1CCc1cnc(Nc3ccc(cc3OC)N3CCN(C)CC3)nc-21
Formula: C33H39N7O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: NTRC-0066-0 is a a highly potent and selective inhibitor of TTK. NTRC 0066-0 inhibits the phosphorylation of a TTK substrate and induces chromosome missegregation. NTRC 0066-0 inhibits tumor growth in MDA-MB-231 xenografts as a single agent after oral application. The combination of NTRC 0066-0 with a therapeutic dose of docetaxel resulted in doubling of mouse survival and extended tumor remission, without toxicity.
Molecular Weight: 565, 722
