Product Overview
NU6140 | T16359 | TargetMol Chemicals
CAS: 444723-13-1
Smiles: CCN(CC)C(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1
Formula: C23H30N6O2
Pathway: Cell Cycle/Checkpoint|||Chromatin/Epigenetic
Target: CDK|||Aurora Kinase
Receptor: N/A
Bioactivity: NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
Molecular Weight: 422, 533