Product Overview
NVP-2 | T16363 | TargetMol Chemicals
CAS: 1263373-43-8
Smiles: COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1
Formula: C27H37ClN6O2
Pathway: Apoptosis|||Cell Cycle/Checkpoint
Target: Apoptosis|||CDK
Receptor: N/A
Bioactivity: NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).
Molecular Weight: 513, 08
