Product Overview
NVP-BHG712 | T6348 | TargetMol Chemicals
CAS: 940310-85-0
Smiles: Cc1ccc(cc1Nc1nc(nc2n(C)ncc12)-c1cccnc1)C(=O)Nc1cccc(c1)C(F)(F)F
Formula: C26H20F3N7O
Pathway: Angiogenesis|||Cytoskeletal Signaling|||MAPK|||Tyrosine Kinase/Adaptors
Target: Raf|||Bcr-Abl|||Src|||Ephrin Receptor
Receptor: N/A
Bioactivity: NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.
Molecular Weight: 503, 489
