Product Overview
NVP-TAE 226 | T1918 | TargetMol Chemicals
CAS: 761437-28-9
Smiles: CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl
Formula: C23H25ClN6O3
Pathway: Angiogenesis|||Apoptosis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||FAK|||c-Met/HGFR|||PYK2|||IGF-1R
Receptor: N/A
Bioactivity: NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.
Molecular Weight: 468, 94
