Product Overview
Nyasol | TN4683 | TargetMol Chemicals
CAS: 96895-25-9
Smiles: Oc1ccc(\C=C/[C@@H](C=C)c2ccc(O)cc2)cc1
Formula: C17H16O2
Pathway: Cytoskeletal Signaling|||Immunology/Inflammation|||MAPK|||Microbiology/Virology|||NF-Κb|||PI3K/Akt/mTOR signaling
Target: ERK|||IL Receptor|||IκB/IKK|||NOS|||NF-κB|||Akt|||Antifection
Receptor: N/A
Bioactivity: Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly effective in suppressing the Phytophthora blight on pepper plants. (-)-Nyasol exhibits the half maximal inhibitory concentration (IC50) value of 17.6 uM against D-glycero-α-D-manno-heptose-1-phosphate guanylyltransferase (HddC). (+)-Nyasol has antiprotozoal activity, it potently inhibits the growth of Leishmania major promastigotes, the IC50 being 12 microM, and moderately inhibits Plasmodium falciparum schizonts with the IC50 49 microM.
Molecular Weight: 252, 31
