Product Overview
O-Desmethyl gefitinib | T16369 | TargetMol Chemicals
CAS: 847949-49-9
Smiles: Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Formula: C21H22ClFN4O3
Pathway: Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Target: EGFR
Receptor: N/A
Bioactivity: O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.
Molecular Weight: 432, 88
