Product Overview
Obtustatin | TP1974 | TargetMol Chemicals
CAS: TP1974
Smiles:
Formula: C184H284N52O57S8
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
Molecular Weight: 4393, 07
