Product Overview
Olodanrigan | T4431 | TargetMol Chemicals
CAS: 1316755-16-4
Smiles: COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1
Formula: C32H29NO5
Pathway: Endocrinology/Hormones
Target: RAAS
Receptor: N/A
Bioactivity: EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA401 blocks p38, p42/p44 mitogen-activated protein kinase (MAPK) activation, neurite outgrowth in adult rat DRG neurons, and sensitization of adult rat and human DRG neurons induced by AngII. It inhibits capsaicin responses in cultured hDRG neurons.
Molecular Weight: 507, 58
