Product Overview
Oltipraz | T0153 | TargetMol Chemicals
CAS: 64224-21-1
Smiles: Cc1c(ssc1=S)-c1cnccn1
Formula: C8H6N2S3
Pathway: Angiogenesis|||Chromatin/Epigenetic|||Metabolism|||Microbiology/Virology|||Others|||Proteases/Proteasome
Target: Others|||HIF/HIF Prolyl-Hydroxylase|||HIV Protease|||Reverse Transcriptase|||HIF
Receptor: N/A
Bioactivity: Oltipraz is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.
Molecular Weight: 226, 33
