Product Overview
Olutasidenib | T16384 | TargetMol Chemicals
CAS: 1887014-12-1
Smiles: C[C@H](Nc1ccc(C#N)n(C)c1=O)c1cc2cc(Cl)ccc2[nH]c1=O
Formula: C18H15ClN4O2
Pathway: Metabolism
Target: Dehydrogenase|||Isocitrate Dehydrogenase (IDH)
Receptor: N/A
Bioactivity: Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Isocitrate dehydrogenase 1 (IDH1) (IC50: 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively).
Molecular Weight: 354, 79