Product Overview
ON-01910 | T6070 | TargetMol Chemicals
CAS: 1225497-78-8
Smiles: [Na+].COc1cc(OC)c(\C=C\S(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1
Formula: C21H24NNaO8S
Pathway: Cell Cycle/Checkpoint
Target: PLK
Receptor: N/A
Bioactivity: ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
Molecular Weight: 473, 47