Product Overview
Onatasertib | T3351 | TargetMol Chemicals
CAS: 1228013-30-6
Smiles: CO[C@H]1CC[C@@H](CC1)N1C(=O)CNc2ncc(nc12)-c1ccc(nc1)C(C)(C)O
Formula: C21H27N5O3
Pathway: Angiogenesis|||Apoptosis|||DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||c-Fms|||DNA-PK|||FLT|||PI3K|||mTOR
Receptor: N/A
Bioactivity: CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. CC-223 is a potent mTOR kinase inhibitor (IC50: 16 nM), with >150-fold sensitivity than the related lipid kinase PI3Kα (IC50: 4 μM).
Molecular Weight: 397, 479
