Product Overview
Ono-3307 mesylate | T28248 | TargetMol Chemicals
CAS: 76472-29-2
Smiles: CS(O)(=O)=O.NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc(cc1)S(N)(=O)=O
Formula: C15H18N4O7S2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Ono-3307 is a protease inhibitor potentially for the treatment of thrombosis. ONO-3307 competitively inhibited trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein and chymotrypsin; and their Ki values were 0.048 microM, 0.18 microM, 0.29 microM, 0.31 microM, 3.6 microM and 47 microM, respectively. In addition, ONO-3307 inhibited both elastase release from N-formyl-Met-Leu-Phe (fMLP)-stimulated leukocytes and tissue thromboplastin release from endotoxin-stimulated leukocytes. ONO-3307 exhibits a wide range of inhibitory effects on various proteases, and ONO-3307 may be useful for the treatment of protease-mediated diseases such as thrombosis and DIC.
Molecular Weight: 430, 45
