Product Overview
Onvansertib | T6247 | TargetMol Chemicals
CAS: 1034616-18-6
Smiles: CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1
Formula: C24H27F3N8O3
Pathway: Apoptosis|||Cell Cycle/Checkpoint
Target: Apoptosis|||PLK
Receptor: N/A
Bioactivity: NMS-P937 (NMS1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3.
Molecular Weight: 532, 528