Product Overview
Orantinib | T6184 | TargetMol Chemicals
CAS: 252916-29-3
Smiles: Cc1[nH]c(\C=C2/C(=O)Nc3ccccc23)c(C)c1CCC(O)=O
Formula: C18H18N2O3
Pathway: Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||VEGFR|||FGFR|||PDGFR
Receptor: N/A
Bioactivity: TSU-68, a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2 and does not suppresses EGFR.
Molecular Weight: 310, 353
