Product Overview
ORY-1001 free base | T28269 | TargetMol Chemicals
CAS: 1431304-21-0
Smiles: NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1
Formula: C15H22N2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers (EC50 me2H3K4 and FACS CD11b <1nM). ORY-1001 induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells (EC50 <1nM). ORY-1001 does not inhibit non-related histone modifiers.
Molecular Weight: 230, 355
