Product Overview
OTS514 | T4134L | TargetMol Chemicals
CAS: 1338540-63-8
Smiles: Cl.C[C@@H](CN)c1ccc(cc1)-c1c(O)cc(C)c2[nH]c(=O)c3sccc3c12
Formula: C21H21ClN2O2S
Pathway: Apoptosis|||MAPK
Target: Apoptosis|||TOPK
Receptor: N/A
Bioactivity: OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
Molecular Weight: 400, 92
