Product Overview
Palbociclib-propargyl | T18515 | TargetMol Chemicals
CAS: 2366269-23-8
Smiles: CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CC#C)CC3)nc2n(C2CCCC2)c1=O
Formula: C27H31N7O2
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1].
Molecular Weight: 485, 592
