Product Overview
Palbociclib | T1785 | TargetMol Chemicals
CAS: 571190-30-2
Smiles: c1(nc2c(cn1)c(c(c(=O)n2C1CCCC1)C(=O)C)C)Nc1ccc(cn1)N1CCNCC1
Formula: C24H29N7O2
Pathway: Cell Cycle/Checkpoint
Target: CDK
Receptor: N/A
Bioactivity: Palbociclib is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation.
Molecular Weight: 447, 54
