Product Overview
Pamiparib maleate | T28293 | TargetMol Chemicals
CAS: 2086689-94-1
Smiles: OC(=O)\C=C/C(O)=O.C[C@]12CCCN1Cc1n[nH]c(=O)c3cc(F)cc4[nH]c2c1c34
Formula: C20H19FN4O5
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis.
Molecular Weight: 414, 393
