Product Overview
PD146176 | T7530 | TargetMol Chemicals
CAS: 4079-26-9
Smiles: C1Sc2ccccc2-c2[nH]c3ccccc3c12
Formula: C15H11NS
Pathway: Apoptosis|||Autophagy|||Cell Cycle/Checkpoint|||Metabolism
Target: Ferroptosis|||Lipoxygenase|||Autophagy
Receptor: N/A
Bioactivity: PD146176 is an inhibitor of 15-Lipoxygenase (15-LO), it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
Molecular Weight: 237, 32