Product Overview
Penciclovir | T1643 | TargetMol Chemicals
CAS: 39809-25-1
Smiles: Nc1nc2n(CCC(CO)CO)cnc2c(=O)[nH]1
Formula: C10H15N5O3
Pathway: Microbiology/Virology|||Proteases/Proteasome
Target: HCV Protease|||Antifection|||HSV
Receptor: N/A
Bioactivity: Penciclovir is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.
Molecular Weight: 253, 262
