Product Overview
PF-03715455 | T16477 | TargetMol Chemicals
CAS: 1056164-52-3
Smiles: CC(C)(C)c1cc(NC(=O)NCc2ccccc2Sc2ccc3nnc(-c4ccccc4SCCO)n3c2)n(n1)-c1ccc(O)c(Cl)c1
Formula: C35H34ClN7O3S2
Pathway: MAPK
Target: p38 MAPK
Receptor: N/A
Bioactivity: PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-03715455 has the potential for the treatment of COPD.
Molecular Weight: 700, 27
